Germany are heavy favorites after beating Serbia 2-0 in October with dominant statistics (32 shots to 1, 3.81 xG to 0.01), while Serbia remain winless in four Nations League matches with zero points and have lost six straight overall. Germany's superior possession (63% vs 34%), shot accuracy, and defensive record (0.71 goals conceded per match vs Serbia's 2.00) support the forecast, though Germany will miss key players including Musiala and Gnabry.